2. Signaling Pathways
  3. GPCR/G Protein
  4. Prostaglandin Receptor

Prostaglandin Receptor

Prostaglandin Receptor

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Prostaglandin receptor, a sub-family of cell surface seven-transmembrane receptors, are the G-protein-coupled receptors. There are currently ten known prostaglandin receptors on various cell types. Prostaglandins bind to a subfamily of cell surface seven-transmembrane receptors, G-protein-coupled receptors. These receptors are named: DP1-2-DP1, DP2 receptors, EP1-4-EP1, EP2, EP3, EP4 receptors, FP-FP, IP1-2-IP1, IP2 receptors, TP-TP receptor. The prostaglandins are a group of hormone-like lipid compounds that are derived enzymatically from fatty acids and have important functions in the animalbody. There are currently ten known prostaglandin receptors on various cell types.

Prostaglandin Receptor Isoform Specific Products:

Prostaglandin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-134511
    15(S)-HpEPE
    		Inhibitor
    15(S)-HpEPE is a product of lipoxygenase hydrolysis of unsaturated fatty acids (PUFA) and is a potential inhibitor of prostaglandin H synthase 2 (PGHS-2). 15(S)-HpEPE can downregulate the expression of PGHS-2.
    15(S)-HpEPE
  • HY-114961
    15-epi Prostaglandin A1
    		Control
    15-epi Prostaglandin A1 (15-epi PGA1) is the 15(R) stereoisomer of PGA1. PGA1 causes renal vasodilation, increased urine sodium excretion, and decreased arterial pressure in hypertensive models.
    15-epi Prostaglandin A1
  • HY-174144
    RJG-2036
    		Inhibitor
    RJG-2036 is a potent covalent inhibitor of human prostaglandin reductase 2 (PTGR2)(IC50=100 nM). RJG-2036 inhibits NADPH-dependent reduction, significantly reducing secretion of proinflammatory cytokines like TNF-α and multiple eicosanoids in LPS-stimulated THP-1 macrophages. RJG-2036 is promising for research of inflammatory diseases.
    RJG-2036
  • HY-137908
    11β-Misoprostol
    		Control
    11β-Misoprostol is one of several impurities which are possible in the production of Misoprostol. Misoprostol is a 15-deoxy-l6-hydroxy-l6-methyl analog of prostaglandin El (PGE1).
    11β-Misoprostol
  • HY-119973
    CAY10397
    		Inhibitor
    CAY10397 is a 15-hydroxyprostaglandin dehydrogenase inhibitor. It has the activity of inhibiting endothelial cell proliferation. CAY10397 can inhibit 15-hydroxyprostaglandin dehydrogenase, thereby affecting the metabolism of 11-oxoeicosatetraenoic acid (11-oxoeicosatetraenoic acid), which can inhibit endothelial cell proliferation.
    CAY10397
  • HY-101952S1
    Prostaglandin E2-d9
    		Activator
    Prostaglandin E2-d9 is the deuterium labeled Prostaglandin E2. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation.
    Prostaglandin E2-d<sub>9</sub>
  • HY-106619
    Seprilose
    Seprilose (GW 80126) is a prostaglandin E2 inhibitor that can inhibit prostaglandin E2 synthesis.
    Seprilose
  • HY-168397
    tetranor-Prostaglandin E1
    tetranor-Prostaglandin E1 is metabolite of Prostaglandin E1 (HY-B0131) and Prostaglandin E2 (HY-101952) that is formed by β-oxidation.
    tetranor-Prostaglandin E1
  • HY-120665
    Prostaglandin B1
    Prostaglandin B1 (PGB1) is a metabolite of Prostaglandin E1 (HY-B0131). Prostaglandin E1 is a prostanoid receptor ligand.
    Prostaglandin B1
  • HY-157002
    Prostaglandin E2 isopropyl ester
    Prostaglandin E2 isopropyl ester (PGE2 isopropyl ester) is the precursor of PGE2.
    Prostaglandin E2 isopropyl ester
  • HY-108560A
    15(S)-Fluprostenol
    		Activator
    15(S)-Fluprostenol is the isomer of (+)-Fluprostenol (HY-108560). (+)-Fluprostenol is a potent agonist of PTGER2. (+)-Fluprostenol decreases the expression of Oviductal glycoprotein 1 (OVGP1).
    15(S)-Fluprostenol
  • HY-12956S2
    Dinoprost-13C5
    		Agonist
    Dinoprost-13C5 is 13C labeled Dinoprost (HY-12956). Dinoprost (Prostaglandin F2α) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost plays a key role in the onset and progression of labour.
    Dinoprost-<sup>13</sup>C<sub>5</sub>
  • HY-173418
    Carbaprostacyclin-biotin
    		Agonist
    Carbaprostacyclin-biotin (cPGI-biotin; Carbacyclin-biotin) is a biotin-bound Carbacyclin (Carbaprostacyclin) (HY-112322). Carbacyclin is a PGI2 analogue, acts as a prostacyclin (PGI2) receptor agonist and vasodilator, and potently inhibits platelet aggregation.
    Carbaprostacyclin-biotin
  • HY-16357
    Octimibate
    		Agonist
    Octimibate is a non-prostaglandin platelet aggregation inhibitor and cycloprostaglandin agonist. Octimibate can be used in the study of cardiovascular diseases (atherosclerosis and thrombosis).
    Octimibate
  • HY-114867
    (15R)-Bimatoprost
    		Control
    (15R)-Bimatoprost (15(R)-17-phenyl trinor PGF2α ethyl amide) is a prostaglandin analog used to treat glaucoma and ocular hypertension. (15R)-Bimatoprost is an isomer of Bimatoprost with an inverted (β) hydroxyl group on C-15.
    (15R)-Bimatoprost
  • HY-119762
    Spizofurone
    Spizofurone is an anti-ulcer compound with increased gastric mucosal blood flow activity and oral activity. Spizofurone has a similar mechanism of action to PGE2 (HY-101952), Spizofurone is capable of acting through local and systemic pathways and may promote ulcer healing by improving blood supply to the gastric mucosa. Spizofurone can be used to study the development strategy of gastric ulcer.
    Spizofurone
  • HY-100286
    MDL 19301
    		Inhibitor
    MDL 19301 is a nonsteroidal, anti-inflammatory agent.
    MDL 19301
  • HY-153256
    EP3 antagonist 4
    		Antagonist
    EP3 antagonist 4 (Compound 28) is an EP3 antagonist, with a Ki value of 2 nM for hEP. EP3 antagonist 4 shows low in vivo clearance, high oral AUC, and good bioavailability in the rat full PK studies. EP3 antagonist 4 can be used for research of beta cell dysfunction in diabetes.
    EP3 antagonist 4
  • HY-117061
    Prostaglandin F2α alcohol methyl ether
    		Agonist
    Prostaglandin F2α alcohol methyl ether is an alcohol methyl ether G protein-coupled receptor. Prostaglandin F2α is also a luteinizing hormone in sheep and may be a nociceptive mediator in the spinal cord.
    Prostaglandin F2α alcohol methyl ether
  • HY-N0761AS
    trans-Isoferulic acid-d3
    trans-Isoferulic acid-d3 is the deuterium labeled trans-Isoferulic acid. trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity.trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1).
    trans-Isoferulic acid-d<sub>3</sub>
Cat. No. Product Name / Synonyms Application Reactivity
Prostaglandin Receptor Isoform Comparison

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